Sequence?Selective Protection of Peptides from Proteolysis

Proteolysis of proteins and peptides is involved in the infection cells by enveloped viruses also invasion spread cancer cells. Shutting down broad-specificity proteases, however, problematic because normal functions these proteases will be affected. Herein, nanoparticle receptors were prepared from molecular imprinting for complex biological peptides. Their strong selective binding enabled them to protect their targeted sequences proteolysis aqueous solution at stoichiometric amounts. Generality method was demonstrated protection hydrophobic hydrophilic different a segment long peptide, peptide mixture. Most interestingly, two targeting parts could work cooperation overall sequence, highlighting versatility method.